What We Should Expect from an Innovative Intra-Articular Hyaluronic Acid Product: Expert Opinion Based on a Comprehensive Review of the Literature

J. Clin. Med. 2023, 12(23), 7422; Submission received: 5 November 2023 / Revised: 22 November 2023 / Accepted: 23 November 2023 / Published: 30 November 2023


New Trends in Pharmacological Treatments for Osteoarthritis.

Cai X, Yuan S, Zeng Y, Wang C, Yu N, Ding C.Front Pharmacol. 2021 Apr 15;12:645842. doi: 10.3389/fphar.2021.645842. eCollection 2021.


New Trends in Injection-Based Therapy for Thumb-Base Osteoarthritis: Where Are We and where Are We Going?

Tenti S, Cheleschi S, Mondanelli N, Giannotti S, Fioravanti A.  Front Pharmacol. 2021 Apr 13;12:637904..


Moving toward targeting the right phenotype with the right platelet-rich plasma (PRP) formulation for knee osteoarthritis.

Andia I, Atilano L, Maffulli N.Ther Adv Musculoskelet Dis. 2021 Mar 29;13:


Intraarticular injection of bone marrow-derived mesenchymal stem cells enhances regeneration in knee osteoarthritis.

Doyle EC, Wragg NM, Wilson SL.Knee Surg Sports Traumatol Arthrosc. 2020 Dec;28(12):3827-3842.


The powerful placebo effect in osteoarthritis.

Zhang W.Clin Exp Rheumatol. 2019 Sep-Oct;37 Suppl 120(5):118-123.

The perspectives of intra-articular therapy in the management of osteoarthritis.

Migliore A, Paoletta M, Moretti A, Liguori S, Iolascon G.Expert Opin Drug Deliv. 2020 Sep;17(9):1213-1226.


Efficacy of a Single Intra-Articular HYMOVIS ONE Injection for Managing Symptomatic Hip Osteoarthritis: A 12-Month Follow-Up Retrospective Analysis of the ANTIAGE Register Data.

Migliore A, Frediani B, Gigliucci G, Foti C, Crimaldi S, De Lucia O, Iolascon G.Orthop Res Rev. 2020 Mar 4;12:19-26.


Intramuscular Clodronate in Long-Term Treatment of Symptomatic Knee Osteoarthritis: A Randomized Controlled Study.

Frediani B, Toscano C, Falsetti P, Nicosia A, Pierguidi S, Migliore A, Giannotti S, Cantarini L, Conticini E.Drugs R D. 2020 Mar;20(1):39-45.


It Is the Time to Think About a Treat-to-Target Strategy for Knee Osteoarthritis.

Migliore A, Gigliucci G, Petrella RJ, Bannuru RR, Chevalier X, Maheu E, Raman R, Herrero-Beaumont G, Isailovic N, Matucci Cerinc M.Ther Clin Risk Manag. 2019 Dec 23;15:1479-1482.


Treat-to-target strategy for knee osteoarthritis. International technical expert panel consensus and good clinical practice statements.

Migliore A, Gigliucci G, Alekseeva L, Avasthi S, Bannuru RR, Chevalier X, Conrozier T, Crimaldi S, Damjanov N, de Campos GC, Diracoglu D, Herrero-Beaumont G, Iolascon G, Ionescu R, Isailovic N, Jerosch J, Lains J, Maheu E, Makri S, Martusevich N, Matucci Cerinc M, Micu M, Pavelka K, Petrella RJ, Tarantino U, Raman R.Ther Adv Musculoskelet Dis. 2019 Dec 19;11


Cost-effectiveness and budget impact analysis of viscosupplementation with hylan G-F 20 for knee and hip osteoarthritis.

Migliore A, Integlia D, Pompilio G, Di Giuseppe F, Aru C, Brown T.Clinicoecon Outcomes Res. 2019 Jul 22;11:453-464.

Intraarticular treatment options for knee osteoarthritis.

Jones IA, Togashi R, Wilson ML, Heckmann N, Vangsness CT Jr.Nat Rev Rheumatol. 2019 Feb;15(2):77-90.


Appropriateness of clinical criteria for the use of SYmptomatic Slow-Acting Drug for OsteoArthritis (SYSADOA). A Delphi Method Consensus initiative among experts in Italy.

Bernetti A, Mangone M, Villani C, Alviti F, Valeo M, Grassi MC, Migliore A, Viora U, Adriani E, Quirino N, Fioravanti A, Paoloni M.Eur J Phys Rehabil Med. 2019 Oct;55(5):658-664.


Safety of Paracetamol in Osteoarthritis: What Does the Literature Say?

Conaghan PG, Arden N, Avouac B, Migliore A, Rizzoli R.Drugs Aging. 2019 Apr;36(Suppl 1):7-14.


Safety of Intraarticular Hyaluronic Acid Injections in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis.

Honvo G, Reginster JY, Rannou F, Rygaert X, Geerinck A, Rabenda V, McAlindon T, Charles A, Fuggle N, Cooper C, Curtis E, Arden N, Avouac B, Bruyère O.Drugs Aging. 2019 Apr;36(Suppl 1):101-127.


Use of viscosupplementation for the recovery of active football players complaining of knee pain.

Migliore A, Giannini S, Bizzi E, Massafra U, Cassol M, Abilius MJM, Boni G.Open Access J Sports Med. 2018 Dec 24;10:11-15.

Why we should definitely include intra-articular hyaluronic acid as a therapeutic option in the management of knee osteoarthritis: Results of an extensive critical literature review.

Maheu E, Bannuru RR, Herrero-Beaumont G, Allali F, Bard H, Migliore A.Semin Arthritis Rheum. 2019 Feb;48(4):563-572. doi: 10.1016/j.semarthrit.2018.06.002. Epub 2018 Jun 19.


EUROVISCO Guidelines for the Design and Conduct of Clinical Trials Assessing the Disease-Modifying Effect of Knee Viscosupplementation.

Henrotin Y, Chevalier X, Raman R, Richette P, Montfort J, Jerosch J, Baron D, Bard H, Carrillon Y, Migliore A, Conrozier T.Cartilage. 2020 Jan;11(1):60-70. doi: 10.1177/1947603518783521. Epub 2018 Jul 4.PMID: 29972025 Free PMC article. 

EUROVISCO Recommendations for Optimizing the Clinical Results of Viscosupplementation in Osteoarthritis.

Conrozier T, Monfort J, Chevalier X, Raman R, Richette P, Diraçoglù D, Bard H, Baron D, Jerosch J, Migliore A, Henrotin Y. Cartilage. 2018 Jun 1:


Intra-articular therapy in hip osteoarthritis.

Migliore A, Anichini S. Clin Cases Miner Bone Metab. 2017 May-Aug;14(2):179-181. doi: 10.11138/ccmbm/2017.14.1.179. Epub 2017 Oct 25. Review.


Decision Algorithms for the Retreatment with Viscosupplementation in Patients Suffering from Knee Osteoarthritis: Recommendations from the EUROpean VIScosupplementation COnsensus Group (EUROVISCO).

Raman R, Henrotin Y, Chevalier X, Migliore A, Jerosch J, Montfort J, Bard H, Baron D, Richette P, Conrozier T.

Cartilage. 2017 Feb 1:1947603517693043.


The challenge of the definition of early symptomatic knee osteoarthritis: a proposal of criteria and red flags from an international initiative promoted by the Italian Society for Rheumatology.

Migliore A, Scirè CA, Carmona L, Herrero-Beaumont G, Bizzi E, Branco J, Carrara G, Chevalier X, Collaku L, Aslanidis S, Denisov L, Di Matteo L, Bianchi G, Diracoglu D, Frediani B, Maheu E, Martusevich N, Bagnato GF, Scarpellini M, Minisola G, Akkoc N, Ramonda R, Barskova T, Babic-Naglic D, Muelas JVM, Ionescu R, Rashkov R, Damjanov N, Cerinic MM.

Rheumatol Int. 2017 Aug;37(8):1227-1236.


Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.

Iolascon G, Gimigliano R, Bianco M, De Sire A, Moretti A, Giusti A, Malavolta N, Migliaccio S, Migliore A, Napoli N, Piscitelli P, Resmini G, Tarantino U, Gimigliano F.

J Nutr Health Aging. 2017;21(5):527-538.


HyalOne® in the treatment of symptomatic hip OA – data from the ANTIAGE register: seven years of observation.

Migliore A, Massafra U, Frediani B, Bizzi E, Sinelnikov Yzchaki E, Gigliucci G, Cassol M, Tormenta S.

Eur Rev Med Pharmacol Sci. 2017 Apr;21(7):1635-1644.


Use of Intra-Articular Hyaluronic Acid in the Management of Knee Osteoarthritis in Clinical Practice.

Cooper C, Rannou F, Richette P, Bruyère O, Al-Daghri N, Altman RD, Luisa Brandi M, Collaud Basset S, Herrero-Beaumont G, Migliore A, Pavelka K, Uebelhart D, Reginster JY.

Arthritis Care Res (Hoboken). 2017 Jan 24.


Differences among Branded Hyaluronic Acids in Italy, Part 1: Data from In Vitro and Animal Studies and Instructions for Use.

Migliore A, Bizzi E, De Lucia O, Delle Sedie A, Bentivegna M, Mahmoud A, Foti C.

Clin Med Insights Arthritis Musculoskelet Disord. 2016 May 25;9:89-101. doi: 10.4137/CMAMD.S38857.


AMSSM scientific statement concerning viscosupplementation injections for knee osteoarthritis: importance for individual patient outcomes.

Trojian TH, Concoff AL, Joy SM, Hatzenbuehler JR, Saulsberry WJ, Coleman CI.Br J Sports Med. 2016 Jan;50(2):84-92.


A double blind randomized active-controlled clinical trial on the intra-articular use of Md-Knee versus sodium hyaluronate in patients with knee osteoarthritis (“Joint”).

Martin Martin LS, Massafra U, Bizzi E, Migliore A.

BMC Musculoskelet Disord. 2016 Feb 22;17:94. doi: 10.1186/s12891-016-0948-4.


Appropriateness of clinical and organizational criteria for intra-articular injection therapies in osteoarthritis. A Delphi method consensus initiative among experts in Italy.

Paoloni M, Bernetti A, Belelli A, Brignoli O, Buoso S, Caputi AP, Catani F, Coclite D, Fini M, Mantovani L, Migliore A, Napoletano A, Viora U, Santilli V.

Ann Ist Super Sanita. 2015;51(2):131-8. doi: 10.4415/ANN_15_02_11.


Consensus statement on viscosupplementation with hyaluronic acid for the management of osteoarthritis.

Henrotin Y, Raman R, Richette P, Bard H, Jerosch J, Conrozier T, Chevalier X, Migliore A.

Semin Arthritis Rheum. 2015 Oct;45(2):140-9. doi: 10.1016/j.semarthrit.2015.04.011. Review.


The discrepancy between recommendations and clinical practice for viscosupplementation in osteoarthritis: mind the gap!

Migliore A, Bizzi E, Herrero-Beaumont J, Petrella RJ, Raman R, Chevalier X.

Eur Rev Med Pharmacol Sci. 2015 Apr;19(7):1124-9. Review.


Duration of symptom relief after intra-articular injection of hyaluronic acid combined with sorbitol (anti-ox-vs) in symptomatic hip osteoarthritis.

Migliore A, Massafra U, Bizzi E, Tormenta S, Cassol M, Granata M.

Int J Immunopathol Pharmacol. 2014 Apr-Jun;27(2):245-52.


Italian Society for Rheumatology recommendations for the management of hand osteoarthritis.

Manara M, Bortoluzzi A, Favero M, Prevete I, Sciré CA, Bagnato G, Bianchi G, Ceruso M, Checchia GA, D’Avola GM, Di Giacinto G, Frediani B, Lombardi A, Mannoni A, Mascheroni G, Matucci Cerinic M, Punzi L, Richelmi P, Scarpellini M, Torretta F, Migliore A, Ramonda R, Minisola G; Italian Society for Rheumatology. Reumatismo. 2013 Oct 31;65(4):167-85. doi: 10.4081/reumatismo.2013.167.


Local approaches to sacro-iliac joint pathologies: several unanswered questions.

Bizzi E, Migliore A. Curr Med Res Opin. 2014 Mar;30(3):489-91. doi: 10.1185/03007995.2013.860022. No abstract available.


Socioeconomic burden of total joint arthroplasty for symptomatic hip and knee osteoarthritis in the Italian population: A 5-year analysis based on hospitalization records.

Piscitelli P, Iolascon G, Di Tanna G, Bizzi E, Chitano G, Argentiero A, Neglia C, Giolli L, Distante A, Gimigliano R, Brandi ML, Migliore A. Arthritis Care Res (Hoboken). 2012 Apr 17. doi: 10.1002/acr.21706. [Epub ahead of print]


The impact of treatment with hylan G-F 20 on progression to total hip arthroplasty in patients with symptomatic hip OA: A retrospective study.

Migliore A, Bizzi E, Massafra U, Bella A, Piscitelli P, Laganà B, Tormenta S. Curr Med Res Opin. 2011 Nov 30.


Hip viscosupplementation under ultra-sound guidance riduces NSAID consumption in symptomatic hip osteoarthritis patients in a long follow-up. Data from Italian registry. Migliore A, Granata M, Tormenta S, Laganà B, Piscitelli P, Bizzi E, Massafra U, Alimonti A, Maggi C, De Chiara R, Iannessi F, Sanfilippo A, Sotera R, Scapato P, Carducci S, Persod P, Denaro S, Camminiti M, Pagano MG, Bagnato G, Iolascon G. Eur Rev Med Pharmacol Sci. 2011 Jan;15(1):25-34.


Hylan g-f 20: review of its safety and efficacy in the management of joint pain in osteoarthritis. Migliore A, Giovannangeli F, Granata M, Laganà B. Clin Med Insights Arthritis Musculoskelet Disord. 2010 Sep 20;3:55-68.


Viscosupplementation in the management of ankle osteoarthritis: a review. Migliore A, Giovannangeli F, Bizzi E, Massafra U, Alimonti A, Laganà B, Diamanti Picchianti A, Germano V, Granata M, Piscitelli P. Arch Orthop Trauma Surg. 2011 Jan;131(1):139-47. Epub 2010 Aug 10. Review.


A new technical contribution for ultrasound-guided injections of sacro-iliac joints. Migliore A, Bizzi E, Massafra U, Vacca F, Martin-Martin LS, Granata M, Tormenta S. Eur Rev Med Pharmacol Sci. 2010 May;14(5):465-9.


Viscosupplementation: a suitable option for hip osteoarthritis in young adults. Migliore A, Bizzi E, Massafra U, Vacca F, Alimonti A, Iannessi F, Tormenta S. Eur Rev Med Pharmacol Sci. 2009 Nov-Dec;13(6):465-72.


Comparative, double-blind, controlled study of intra-articular hyaluronic acid (Hyalubrix) injections versus local anesthetic in osteoarthritis of the hip. Migliore A, Massafra U, Bizzi E, Vacca F, Martin-Martin S, Granata M, Alimonti A, Tormenta S. Arthritis Res Ther. 2009;11(6):R183. Epub 2009 Dec 9.


Intra-articular use of hyaluronic acid in the treatment of osteoarthritis. Migliore A, Granata M. Clin Interv Aging. 2008;3(2):365-9. Review.


[Correlation between radiologic and ultrasonographic patterns and clinical manifestations in symptomatic hip osteoarthritis].

Migliore A, Tormenta S, Iannessi F, Mascheroni E, Barbati E, Capuano A, Diaco M, Massafra U, Padalino C, Vacca F, Alimonti A, Martin LS, Granata  Reumatismo. 2007 Jan-Mar;59(1):57-65. Italian.


[18-month observational study on efficacy of intraarticular hyaluronic acid (Hylan G-F 20) injections under ultrasound guidance in hip osteoarthritis].

Migliore A, Tormenta S, Massafra U, Martin Martin LS, Carloni E, Padalino C, Alimonti A, Granata M. Reumatismo. 2006 Jan-Mar;58(1):39-49. Italian.


Efficacy and safety of viscosupplementation by ultrasound-guided intra-articular injection in osteoarthritis of the hip.

Migliore A, Martin LS, Alimonti A, Valente C, Tormenta S. Osteoarthritis Cartilage. 2003 Apr;11(4):305-6. No abstract available.

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